Experimental results indicate that luminal iron sulphate deprivation in combination with systemic iron repletion inhibited the development of inflammation in TNFls Δ ARE/WT mice. The mechanisms implied changes in the gut microbiota as well as inhibition of endoplasmic reticulum stress and apoptosis in the intestinal epithelium.
In conclusion, luminal iron may directly affect intestinal epithelial function or generate a pathological milieu in the intestine that triggers epithelial cell stress-associated apoptosis through changes in the microbial homeostasis. These results suggest that oral replacement therapy with iron sulphate may trigger inflammatory processes associated with progression of CD-like ileitis.
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