In the present thesis, several strategies to address the endocannabinoid system were pursued. Besides the synthesis of well over a hundred potentially active new compounds based on the lead structure of the potent cannabinoid analogs, 3-benzylcoumarins, a formal total synthesis of tetrahydrocannabinol (THC) via an DIELS-ALDER-reaction was concluded.
Additionally, some of the most potent compounds from preceding work have been encapsulated in micro- and nanoparticulate carrier systems. The particles were capable to release their cannabinoid payloads over hours, days, weeks and even months. The described microparticulate carrier systems should be able to generate site specific and long-term stable drug levels.
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