Further, the activation and deactivation of NF-κB is tightly regulated by negative feed-back loops. The transcription of the two NF-κB inhibitors IκBα and A20 is induced by NF-κB itself. In this work, a mathematical model was developed comprising both negative feedbacks to determine if post-transcriptional regulation of the two inhibitor mRNAs by the RNA-binding protein RC3H1 can impact the NF-κB signal transduction. Additionally, the interplay of the two feedbacks was analysed and cell type specific differences were examined. Again, the total NF-κB concentration was found to have a crucial impact. It determines the influence of RC3H1 on the NF-κB activity and the interplay of the two feedbacks.
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