This thesis deals with the effect of system characteristics such as feedback, matter flow properties and kinetics on the period and amplitude sensitivities of oscillating systems. Taking a computational approach, ordinary differential equation models of prototype oscillators are examined for which parameter sets are sampled and sensitivity coeffcients for perturbations of the kinetic parameters are calculated. The detailed analysis shows that besides the feedback type, also matter flow properties and kinetics yield a strong influence on the observed period and amplitude sensitivities. The validity of the results obtained for the prototype oscillators is furthermore examined for published models of calcium and circadian oscillations, and the effect of saturating kinetics is confirmed for models of synthetic oscillators.
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