In this work peptoid analogs of two short amino acid sequences with antitumor activity (one derived from the CD44-v6 coreceptor and one from the BAG-1L protein), have been designed and synthesized. Comparison of the biological activity of the peptides and the different peptoid analogs led to the establishment of structure-activity relationships and the identification of a lead compound showing high potential for cancer therapy. In addition, a method for the synthesis of amide-containing submonomers as free bases and their incorporation into peptoid oligomers is described. Different-length homo-oligomers of $alpha$-chiral amide residues were successfully synthesized for structural investigations.
*You can purchase the eBook (PDF) alone or combined with the printed book (eBundle). In both cases we use the payment service of PayPal for charging you - nevertheless it is not necessary to have a PayPal-account. With purchasing the eBook or eBundle you accept our licence for eBooks.