A general method for the anionic ring-opening polymerization of ethylene oxide and functional epoxides has been developed and utilized for the preparation of a number of multifunctional PEGs and their copolymers with PEG. The obtained polymers were either directly or after post-polymerization modification utilized for the fabrication of biomaterials. Smart hydrogels have been prepared from a multifunctional photoresponsive PEG copolymer and multifunctional hydrazide PEG. Reactive anisotropic particles suitable for either reversible sugar conjugation or dual stimuli (oxidation and UV irradiation) triggered degradation have been fabricated via electrohydrodynamic co-jetting.
These new biomaterials have great potential for applications in tissue engineering and targeted drug delivery with controlled release.
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